Have you ever seen a local commercial or a late-night talk show so bizarre you almost couldn’t look away?

Comics Tim and Eric have made a career out of turning local-access weirdness, awful effects and awkward silences into both laughter and confusion.

Known for their series “Tim and Eric Awesome Show, Great Job!” and “Tim and Eric’s Billion Dollar Movie,” the duo (and special guest John C. Reily as the clueless Dr. Steve Brule) is bringing their touring stage show to the Civic on Friday, Sept. 19.

What do two of the strangest comedians on TV do when they’re standing right in front of you onstage?

Well, they’ll be doing a fair amount of storytelling and improv, as well as promoting their new horror-themed Adult Swim show, “Tim and Eric’s Bedtime Stories,” which premieres Thursday, Sept. 18.

The new show, which will feature several guest stars from the “Tim and Eric” universe, will run for seven episodes.

“Bedtime Stories” is a break from their previous sketch-based comedy in that each episode follows one spooky story to conclusion, which is a bit of a break from the rapid-fire weirdness of their previous shows.

Fans who love or hate “Bedtime Stories” will have the first shot at telling Tim and Eric what they think in person at the show in New Orleans.

Dr. Steve Brule (played by “Wreck It Ralph” star and Oscar nominee John C. Reilly) will be enlightening the audience with dubious “for your health” tips from his show, “Check It Out! With Dr. Steve Brule.”

Tips include how to negate underarm body odor with vinegar, the origins of bones (according to Dr. Steve, they are the junk your muscles throw out) and life-saving self-defense techniques like “kill ’em with kindness” and “playing possum.” Who says that learning can’t be fun?

The tour has been compared by Tim Heidecker to an amped-up version of “Tim and Eric Awesome Show, Great Job!,” a TED talk and a Broadway musical, specifically “Jesus Christ Superstar.”

Together, the duo have stuck their fingers into many different pies, directing and acting in Absolut Vodka commercials, music videos, and Web series, so there’s certainly a lot of material for them to draw on.

The fact is that nobody knows for sure what’s going to happen at a Tim and Eric live show, but that’s the fun of it. Audiences curious enough to “Check it Out!” should expect the unexpected.

Information about “The Tim and Eric and Dr. Steve Brule 2014 Tour” and full episodes of “Awesome Show” and “Check It Out!” can be found attimanderic.com.