Less than 24 hours after one of the Tigers' starting pitchers, sophomore left-hander Cody Glenn, was left off the active roster for violating an unspecified team rule, Friday's starter, Ryan Eades had his worst outing of the season.
To add injury to insult, two of LSU's five All-Southeastern Conference players - shortstop Alex Bregman and left fielder Raph Rhymes - had to leave the game in the fourth inning after colliding as Bregman caught a pop-up.
The players' status for the rest of the double-elimination tournament was not immediately known.
Junior right-hander Kurt McCune (4-1) shut down Jackson State after Eades left and Mason Katz and Jared Foster hit two-run home runs and two sacrifice flies as the Tigers (53-9) overcame the rough start to win easily.
Top-seeded LSU will play the winner of Friday night's game between second-seeded Louisiana-Lafayette and third-seeded Sam Houston State in a winner's bracket game at 7 p.m. Saturday. Fourth-seeded Jackson State (34-21) will play the loser of that game in an elimination game at 2 p.m. Saturday.
With two runners on and two out in the top of the fourth, Rhymes ran in and Bregman ran out after Ethan Bright's popup. Bregman made the running catch, then collided with Rhymes, who fell to the ground.
Both players were examined by medical personnel before walking to the dugout. They were both pinch hit for in the bottom of the inning. Rhymes needed two stitches to fix a cut lip and Bregman was taken to a hospital where he was diagnosed with a concussion.
Eades lasted just 2.1 innings, allowing nine baserunners, and his seven outs included a sacrifice bunt and a caught stealing.
McCune relieved with runners on first and second with one out in the third and got out of it with a strikeout and a groundout. He went on to pitch 4.2 scoreless innings, striking out five.
Kevin Berry relieved McCune to start the eighth with a 10-2 lead and gave up two runs and left with the bases loaded and one out as Nate Fury came in. Fury hit Bryce Taylor to force in a run before striking out the next two batters.
Foster's sacrifice fly, the Tigers' record-tying fourth of the game, completed the LSU scoring in the bottom of the eighth.
Freshman Hunter Newman started the ninth and gave up a two-run homer to Fred Hampton and walked Nick Marigny before giving way to Joey Bourgeois, who got the final three outs.
LSU broke a 2-2 tie in the third. Sean McMullen led off with a single and moved to third on Tyler Moore's hit-and-run single. After Bregman's grounder advanced Moore, Katz's sacrifice fly sent home McMullen with the tiebreaking run. Rhymes walked before Christian Ibarra doubled home Moore for a 4-2 lead.
JaCoby Jones led off the fourth with a single and went to third on Alexander Juday's (7-5) errant pickoff throw. Andrew Stevenson walked before McMullen hit a sacrifice fly.
Stevenson moved to second on a groundout and scored when Chris Sciambra hit for Rhymes and singled to center.
Brandon Gregory relieved and Katz launched his 15th homer of the season off the screen in center field for an 8-2 lead. Katz walked ahead of Foster's home run in the sixth.
The game was just 10 minutes old when rain interrupted play for 25 minutes in the top of the first.
Eades put two runners on before the delay, yielding a leadoff single to Aneko Knowles and after two outs hitting Ethan Bright. When played resumed, Charles Tilery doubled home both runners.
LSU tied the score with some help from JSU in the second. McMullen led off with a single, stole second and went to third on Moore's fly ball.
After Bregman was hit by a pitch, Katz's sacrifice fly sent McMullen home. Bregman stole second, went to third on catcher Jose Cruz's errant pickoff throw and scored on Marigny's throwing error on Rhymes' grounder to short.