PHILADELPHIA — Darren Sproles had two touchdowns, Mark Sanchez threw for two scores and the defense sacked Cam Newton nine times to help the Philadelphia Eagles beat the Carolina Panthers 45-21 Monday night.

Filling in for an injured Nick Foles, Sanchez had 332 yards passing in his first start since Dec. 30, 2012. Sproles returned a punt 65 yards for a score and had an 8-yard TD run. Bradley Fletcher returned an interception 34 yards for a TD and Jordan Matthews had 138 yards receiving and two TDs.

The Eagles (7-2) stayed on top in the NFC East. They’re trying to repeat as division champions without Foles, who broke his collarbone in a win at Houston last week.

The Panthers (3-6-1) hardly look like the team that won the NFC South last year.

Colts

DB Landry will come off bench: In Indianapolis Colts coach Chuck Pagano says safety LaRon Landry will not start Sunday against New England.

He hasn’t played since Sept. 28 after the league imposed a four-game suspension for violating the NFL’s policy on performance-enhancing drugs. Landry, a former LSU standout, was eligible to return Nov. 3 but was not activated until Nov. 4. Indianapolis (6-3) had a bye last weekend.

Sergio Brown replaced Landry in the lineup and is expected to make his sixth consecutive start when the AFC South leaders host the Patriots (7-2).

Two injured starters, defensive tackle Arthur Jones and outside linebacker Erik Walden, worked with the trainers Monday. Pagano has not said if they will play against the Patriots.

NFL

Union files grievance vs. NFL in Peterson case: In Eden Prairie, Minn., the NFL Players Association has filed a grievance with the NFL to reinstate Minnesota Vikings running back Adrian Peterson.

The NFLPA cited Monday “explicit language in a signed agreement” from Sept. 18, when Peterson was placed on a special commissioner’s exempt list following his indictment on felony child abuse in Texas. He pleaded no contest Tuesday to a lesser charge of misdemeanor reckless assault.

The league began a review Thursday of his case under the personal conduct policy, but said Peterson would remain on paid leave until the process is completed.

The union, however, demanded Peterson be allowed to rejoin the Vikings immediately until any determination of any discipline.

Dolphins

Albert out for season with knee injury: In Davie, Fla., Miami Dolphins left tackle Branden Albert will miss the rest of the season because of a right knee injury, triggering a significant reshuffling in the offensive line.

Albert went on injured reserve Monday after being hurt in Miami’s loss at Detroit.

Albert has been perhaps Miami’s best offensive player this year, stabilizing a line that was awful in 2013. He’s in the first year of a $47 million, five-year contract that includes $26 million guaranteed.

To fill Albert’s roster spot, Miami signed running back LaMichael James off the practice squad. James was a second-round draft pick by San Francisco in 2012. The Dolphins (5-4) play at home Thursday against Buffalo (5-4).

Seahawks

Mebane sidelined with hamstring pull: In Renton, Wash.: Seattle Seahawks defensive tackle Brandon Mebane suffered a “really legit” hamstring injury, according to coach Pete Carroll, with no timetable on when he could return.

Mebane’s injury was the biggest blow from Seattle’s 38-17 win over the New York Giants on Sunday. Mebane was injured during the first half of Seattle’s third straight win. Carroll said veteran Kevin Williams would see his snap count increase, with Tony McDaniel and Jordan Hill also stepping in to help replace Mebane.

Tight end Luke Willson suffered a sprained ankle against the Giants and his status for this Sunday’s game at Kansas City is unknown.

Carroll said the team hopes linebacker Malcolm Smith and safety Kam Chancellor will be back this week, but guard James Carpenter is likely out another week.