Baylor quarterback Bryce Petty reacts before an NCAA college football game against Iowa State, Saturday, Sept. 27, 2014, in Ames, Iowa. (AP Photo/Charlie Neibergall)

AMES, Iowa — Bryce Petty threw for 336 yards and a touchdown and ran for a pair of TDs as seventh-ranked Baylor cruised past Iowa State 49-28 in its Big 12 opener Saturday night.

Shock Linwood had three TDs rushing for the Bears (4-0, 1-0 Big 12), who have started 4-0 in back-to-back seasons for the first time in 76 years.

Baylor’s first game against a Power 5 school was a bit more difficult than its first three against weaker competition. But the Bears jumped ahead 35-7 late in the second quarter and led by at least 21 points for the entire second half.

Quarterback Sam Richardson threw for 212 yards and ran for 99 more for Iowa State (1-3, 0-2), which is 0-3 at home.

The Cyclones did make things briefly interesting in the third quarter, pulling within 42-21. But Petty found Corey Coleman for a 42-yard reception that set up Petty’s 1-yard plunge.

The return of receivers Coleman (hamstring) and Antwan Goodley (quadriceps) made Baylor’s offense more explosive than ever. The pair combined for 18 catches, 268 yards and a touchdown.

The high-flying Bears now have 10 touchdown drives where the yards outnumbered the seconds it took to reach the end zone.

NO. 9 MICHIGAN ST. 56, WYOMING 14: In East Lansing, Mich., Jeremy Langford ran for 137 of Michigan State’s 533 yards of total offense.

Michigan State (3-1) completed its most prolific four games in school history with a 50.3-point average.

Connor Cook was 6 of 8 for 109 yards and two touchdowns, helping Michigan State score more than 50 points in consecutive games for the first time since 1978. The Spartans have scored 174 points in three home games heading into a visit from unbeaten No. 21 Nebraska next week.

Wyoming (3-2) finished with 286 yards of offense, but lost the ball on two fumbles and an interception.

NO. 16 STANFORD 20, WASHINGTON 13: In Seattle, Kevin Hogan scored on a 5-yard run with 4:29 remaining, and Stanford took advantage of a poorly timed fake punt to hold off Washington.

Hogan and the Cardinal (3-1, 1-1) avoided a potentially costly 0-2 start in Pac-12 play after already losing at home to Southern California.

Stanford dominated statistically, but was still tied midway through the fourth quarter because of continued problems in the red zone. That’s when Washington coach Chris Petersen took a gamble running a fake punt on fourth-and-9 at the Huskies 47. The play was stuffed and Hogan scored on the ensuing possession.

The Huskies (4-1, 0-1) had 179 total yards, including just 98 passing.

NO. 19 WISCONSIN 27, SOUTH FLORIDA 10: In Madison, Wis., Melvin Gordon rushed for 181 yards and two touchdowns, and Wisconsin overcame a sluggish start to beat South Florida.

Gordon scored on carries of seven and 43 yards on the Badgers’ first two drives of the second half after running room finally opened up for the star tailback.

The Bulls (2-3) put up an admirable effort in their first road contest of the year, getting to 17-10 midway through the third quarter on Rodney Adams’ 26-yard touchdown run off a reverse.

Wisconsin (3-1) inched away in the final 20 minutes to extend its nonconference home winning streak to 32.

No. 22 Ohio St. 50, Cincinnati 28: In Columbus, Ohio, J.T. Barrett passed for 330 yards and four touchdowns and Ezekiel Elliott ran for 182 yards and a score to lead Ohio State past Gunner Kiel and Cincinnati.

Kiel, the acclaimed passer for the Bearcats (2-1), completed 21 of 32 passes for 352 yards and four scores in a game of wild momentum swings before a stadium-record crowd of 108,362.

The Buckeyes (3-1), who won their 40th consecutive game over an in-state opponent, totaled 710 yards. But their defense couldn’t stop the Bearcats, who had wide-out Chris Moore catch three passes for 221 yards and three TDs.

Not until Barrett hit Devin Smith with a 29-yard scoring pass early in the fourth quarter was it clear the Buckeyes would survive.

NO. 25 KANSAS STATE 58, UTEP 28: In Manhattan, Kan., Charles Jones ran for three touchdowns, Tyler Lockett returned a punt for another score and Kansas State romped past UTEP.

DeMarcus Robinson and Jake Waters also had touchdown runs, and Waters threw for 209 yards and another score as the Wildcats (3-1) finished nonconference play.

UTEP (2-2) managed one first down and 23 yards of offense in the first half, when Kansas State raced to a 31-0 lead. Running back Aaron Jones, the nation’s second-leading rusher, was held to 47 yards.

Jameil Showers threw four TD passes for the Miners, all with the game well out of reach.