The official who has headed Interim LSU Hospital over the past two years will be leaving to take a new job about a month after the hospital makes its long-anticipated move to the new University Medical Center this weekend, according to a Thursday announcement.

The news that Cindy Nuesslein will resign as CEO of UMC to take a position with an environmental design and engineering firm came two days before the massive undertaking involved in moving patients and staff into the new, $1.1 billion Mid-City hospital.

Officials with LCMC Health, which will run the new medical center, said that despite the timing, they don’t have any concerns about the transition.

“Cindy is leaving UMC in the best possible hands,” said Greg Feirn, CEO of LCMC Health. “We are supremely confident in the continuing success of this amazing facility and the incredible caregivers that bring it to life.”

Feirn added that Nuesslein’s “depth of experience and expertise in health care and construction made her the perfect leader for the building of and transition to UMC New Orleans, one of our city’s largest and most significant construction projects in decades.”

Nuesslein will be taking a job as a principal with Mazzetti, a national firm that focuses on health care and higher education projects. The firm previously worked with LCMC on the Children’s Hospital neonatal intensive care unit.

Feirn will serve as interim CEO of UMC while the company conducts a national search for Nuesslein’s replacement.

Nuesslein is expected to stay with UMC until at least late August to help with the transition.

Dr. Steve Nelson, dean of the LSU Health Sciences Center’s School of Medicine, said the staff that Nuesslein has assembled will ensure a smooth transition after the “monumental task” of seeing the new facility to completion and preparing for the move to it.

The Health Sciences Center is partnered with UMC and will use the facility as a teaching hospital and for research.

“You never want good people to move on, but at the same time, you wish them great success,” Nelson said.

The relatively small changes that will be made to the hospital’s operations after moving into the new building — other than the change to a new facility itself — will also help ease the transition, he said.

Feirn praised the efforts of the UMC staff in his memo announcing Nuesslein’s resignation.

“Under Cindy’s leadership, you all have worked together to accomplish a herculean task, recasting public health care delivery, and the success of your conjoined efforts creates a legacy that will be celebrated for generations to come,” he said.

Nuesslein has served in various capacities at LCMC Health since 1983. She was Children’s Hospital’s vice president of operations from 1987 to 2013. In March 2013, she was promoted to CEO of Interim LSU Hospital, leading it through the transition from a public hospital to a public-private partnership, expanding its capacity and working toward the move to the new building.

She graduated from Charity Hospital School of Nursing and received a bachelor of science degree and master of business administration degree from Loyola University.

Follow Jeff Adelson on Twitter, @jadelson.