Officials will shut down one eastbound lane of Jefferson Highway at Powerline Drive in Harahan for more than a year beginning on Monday.
Barring unforeseen delays, the closure will last from 7 a.m. Monday to the night of Aug. 16, 2016.
Crews will be installing discharge pipes connecting a pump station to the Mississippi River.
Both westbound lanes and one eastbound lane of Jefferson at Powerline will remain open throughout the work, officials said.
Conti Construction is in charge of installing the discharge pipes, which will cost about $24.2 million.
The work is part of the ongoing construction project commonly referred to as “pump to the river,” which the Army Corps of Engineers says will reduce the threat of flooding in Elmwood and Harahan.
In a statement, Harahan Police Chief Tim Walker and Mayor Tina Miceli said they would monitor the project closely and work with “other public agencies to provide residents with the best options available.”