The Saints entered Sunday as the lone NFL team to be undefeated at home yet winless on the road.
By mid-afternoon, the Saints lost their chance to change their 2014 road woes, falling 24-23 at Detroit.
After leading 23-10 in the fourth quarter, the Saints defense allowed two quick scores - Golden Tate reached the end zone on a 73-yard reception and Glover Quinn's interception with 3:10 left led to Corey Fuller's five-yard TD.
The extra point gave Detroit a one-point lead, ruining a six-catch, 111-yard effort by Marques Colston and Kenny Stills' five-catch, 103-yard effort.
The Saints offense was unable to counter, it's final chance at a rally ending on a forth and three with 21 seconds left. Drew Brees was unable to connect with Robert Meachem.
All-Pro tight end Jimmy Graham played for the Saints, despite a shoulder injury which had kept him out of practice or limited this week. But Graham was held without a catch against the Lions (5-2).
Brees threw for 335 yards and two TDs for the Saints (2-4). Placekicker Shayne Graham converted two fourth-quarter field goals (36, 48), but it proved to not be enough.
Former Saints running back Reggie Bush finished with four carries for 10 yards, while catching five passers for 22 yards. Mathew Stafford threw for 299 yards with two TDs and two INTs.
The Saints this season have now lost road games at Atlanta, Cleveland, Dallas and Detroit.
Next Sunday, the Saints host Green Bay.