An injury-marred opening week of college football began with Arizona star linebacker Scooby Wright tearing cartilage in his left knee and ended with Virginia Tech quarterback Michael Brewer breaking his collarbone.

They are expected to return sometime this season. Plenty of other players weren’t as fortunate.

Pittsburgh running back James Conner, TCU linebacker Sammy Douglas, Notre Dame running back Tarean Folston, BYU quarterback Taysom Hill, Syracuse quarterback Terrel Hunt and UCLA defensive tackle Eddie Vanderdoes suffered likely season-ending injuries.

“Any team that has dreams of playing at the highest level realizes they have to have depth because you’re going to, through the course of the season, have some injuries,” UCLA coach Jim Mora Jr. said. “You have to have quality guys who can come in and fill that role. Most good teams do have that.”

Ohio State overcame injuries to quarterbacks Braxton Miller and J.T. Barrett on the way to winning last year’s national championship with Cardale Jones at the controls.

Some teams already have gone to the depth chart.

With a knee injury sidelining Conner, Pitt freshman Qadree Ollison ran for 207 yards in a 45-37 win over Youngstown State and was chosen Atlantic Coast Conference rookie of the week.

BYU freshman quarterback Tanner Mangum replaced Hill and threw a 42-yard Hail Mary touchdown pass to Mitch Mathews as time expired to give the Cougars a 33-28 victory at Nebraska.

Here’s a rundown of other notable injuries:

MICHAEL BREWER, QB, VIRGINIA TECH

After breaking his collarbone in a 42-24 loss Monday to No. 1 Ohio State, Brewer will miss four to eight weeks.

JAMES CONNER, RB, PITTSBURGH

The reigning ACC player of the year tore the medial collateral ligament in his right knee Saturday.

JESSE ERTZ, QB, KANSAS STATE

Ertz got hurt early in a 34-0 victory over South Dakota. Without detailing the nature of Ertz’s injury, Kansas State coach Bill Snyder said the quarterback would be out “for quite some time.”

TAREAN FOLSTON, RB, NOTRE DAME

Notre Dame’s top returning rusher from last season tore the ACL in his right knee in a 38-3 victory over Texas.

TAYSOM HILL, QB, BYU

He sustained a mid-foot sprain against Nebraska, marking the third time in four years that an injury has ended Hill’s season early.

TERREL HUNT, QB, SYRACUSE

After missing the last seven games of the 2014 season with a broken left calf bone, Hunt injured his right Achilles tendon Friday in a 47-0 win over Rhode Island.

KEVIN WILLIAMS, WR, CLEMSON

Clemson’s top receiver from last season sustained a small fracture in his neck Saturday when he crashed into a padded goal post while making a touchdown catch in a 49-10 rout of Wofford.

SCOOBY WRIGHT, LB, ARIZONA

The 2014 Nagurski Trophy, Lombardi Award and Bednarik Award winner is expected to miss three or four weeks for the 22nd-ranked Wildcats after injuring his knee in Thursday’s 42-32 win over Texas-San Antonio.

Wright had 163 total tackles — 29 for loss — plus 14 sacks and six forced fumbles last season. Wright’s likely replacement is Haden Gregory.