Denver Broncos star wide receiver Wes Welker has been suspended four games due to a positive test for amphetamines, according to multiple reports.

Welker, the star slot receiver who was acquired by Denver from the New England Patriots, tested positive in May, according to reports.

On Tuesday, he lost his appeal the suspension, according to reports.

An NFL official declined to comment on the matter.

An attempt to reach the Broncos for additional comment was unsuccessful.

Texans

WATT SIGNS SIX-YEAR EXTENSION: J.J. Watt couldn’t sleep Monday night after agreeing to a six-year contract extension with the Houston Texans.

The star defensive end arrived at NRG Stadium about 3:30 a.m. and found the security code on the door had changed, keeping him locked out. A cleaning lady let him in, and Watt went straight to the weight room.

“I thought they were pulling a joke on me,” Watt said Tuesday. “I’m not even on the team anymore.”

Not a chance.

Watt’s deal is reportedly worth $100 million, including a $10 million signing bonus and $51.8 million in guaranteed money overall. He’s now signed through the 2021 season.

Colts

IRSAY SUSPENDED, FINED $500,000: The NFL suspended Jim Irsay for the first six games of the season and fined him $500,000 for violating its personal conduct policy, coming down hard on the Indianapolis Colts owner Tuesday just hours after he pleaded guilty to a misdemeanor stemming from an embarrassing March traffic stop.

Commissioner Roger Goodell said Irsay is barred from team facilities, practices and games, and cannot represent the Colts at NFL meetings or events. The fine is the maximum allowed under league rules.

The 55-year-old Irsay pleaded guilty to a misdemeanor count of driving while intoxicated and acknowledged during his appearance before a Hamilton County judge that he was under the influence of the painkillers oxycodone and hydrocodone when he was arrested March 16 near his home in the Indianapolis suburb of Carmel.

Irsay did not comment outside the courtroom, but he apologized to Colts fans in a prepared statement.

49ers

TEAM CLAIMS ZERO TOLERANCE FOR DOMESTIC VIOLENCE: San Francisco General Manager Trent Baalke and coach Jim Harbaugh have made it clear they have zero tolerance for domestic violence and consider defensive tackle Ray McDonald’s arrest a serious matter.

The team is gathering as much information as possible in the wake of the veteran defensive tackle’s arrest Sunday on felony domestic violence charges. Baalke said the organization would let the legal process play out before determining what is next for McDonald with the team.

Baalke said he has had lengthy conversations with McDonald since Sunday.

Harbaugh maintained his firm stance about the topic during his Tuesday radio segment on KNBR-AM, two days after McDonald was arrested during a party for his 30th birthday — which was Tuesday.

Bills

THREE GROUPS IN MIX TO BUY TEAM: Three sources close to discussions told The Associated Press at least three groups have entered final negotiations to buy the Buffalo Bills.

Buffalo Sabres owners Terry and Kim Pegula, real estate mogul Donald Trump and a Toronto-based group that includes rocker Jon Bon Jovi have received formal documents in advance of a bid deadline Monday. The people spoke Tuesday on condition of anonymity because the sale is being conducted privately.

The law firm representing late Bills owner Ralph Wilson’s estate distributed purchase agreements. The agreements are binding documents that require groups to submit a bid, and establish the terms and conditions of a potential sale.

Cowboys

Rookie defensive end Lawrence out at least half season: In Irving, Texas, Dallas Cowboys rookie defensive end DeMarcus Lawrence will miss at least half the season after being placed on the short-term injured list because of a broken right foot.

Lawrence, a second-round pick from Boise State, broke his foot early in training camp and needed surgery. He was in a one-on-one drill with Pro Bowl tackle Tyron Smith when his foot got caught as Smith pushed him to the ground.

The Los Angeles Times and The Associated Press contributed to this report.