EAST RUTHERFORD, N.J. — Andrew Luck threw for four touchdowns and the Indianapolis Colts defense kept Eli Manning and the New York Giants off balance Monday night in Indianapolis’ 40-24 romp.

With his franchise-record seventh consecutive 300-yard game, Luck led the Colts (6-3) to a lopsided win one week after a 51-34 loss to Pittsburgh. Unlike the way Steelers quarterback Ben Roethlisberger toyed with their defense in that game, the Colts didn’t let Manning get going in handing New York (3-5) its third straight defeat.

Giants first-round pick Odell Beckham Jr., a former LSU star, had 156 yards on eight receptions, by far his best game. Manning threw for 359 yards and two touchdowns, but most of that came with the game decided.

Luck hit Coby Fleener for a 32-yard touchdown in the first half. Luck had scoring throws of 31 yards to T.Y. Hilton, 40 yards to Reggie Wayne and 2 yards to Dwayne Allen in the third period.

Adam Vinatieri added four field goals and is perfect on 20 tries this year.

It was the eighth time this season that Luck had thrown for more than 300 yards and the 17th time in his three pro seasons. He was 25-for-46 for 354 yards.

Wayne surpassed James Lofton for career yards receiving and has 14,070 in his 14-season career.