OXFORD, Miss. — The Southeastern Louisiana baseball team gave up five runs in the first inning and never caught up in a 6-2 loss at Ole Miss on Wednesday, dropping a second consecutive game to the Rebels.

Ole Miss (13-1) got the early jump on the Lions (8-4) and chased starting pitcher Kaleb Manuel in the first inning.

After retiring the first batter on a grounder, Manuel (0-1) gave up a pair of singles, then balked. Cleanup hitter Stuart Turner followed with an RBI single, putting runners on the corners.

An infield error and a single then sent coach Jay Artigues digging into his bullpen.

He brought in Jason Greenleaf, who was greeted by a run-scoring single and double before he closed out the inning.

The right-hander settled in, allowing one unearned run in three innings.

The Rebels scored an unearned run in the fourth, when freshman left-hander Brennan Catalano came on for the Lions, stranding a pair of runners in the inning.

Catlano tossed 3.2 scoreless innings in relief.

Southeastern pushed across runs in the fifth and sixth.

Fifth-inning singles by Kyle Cedotal and Brett Hoffman put runners on the corners.

Corey Bryan, pinch-running for Cedotal, scored on a Harry Slade sacrifice fly.

In the sixth, first baseman Tanner Rainey drew a lead-off walk and moved to second on a groundout. He came around to score on an Alex Marse single to right.

John Gremillion worked a scoreless eighth for the Lions, holding the deficit to four. Southeastern loaded the bases with two outs in the ninth, but failed to muster another run.

Ole Miss starter Brady Bramlett (2-0) picked up the win, and Tanner Bailey recorded the final out of the game for his second save.

“I’m certainly happy that we won, but disappointed because I didn’t think we played very well today,” Ole Miss coach Mike Bianco said. “The theme of the game was that we did just enough. We pitched just enough, we hit just enough; we defended just enough to win. You’re trying to get better every day, and I just didn’t think we played very well today — even though we played well enough to win.”

Southeastern travels to Troy, Ala., this weekend for three games. The Lions will play Hartford at 1 p.m. Saturday and again at 10 a.m. Sunday before facing host Troy at 2 p.m. Sunday.

Ole Miss will host Lipscomb in a three-game weekend series.