The Dallas Cowboys defeat the New Orleans Saints 38-17 _lowres

Dallas Cowboys' DeMarco Murray (29) leaps for the end zone for a touchdown in front of New Orleans Saints' Corey White (24) and Ramon Humber, right, during the second half of an NFL football game, Sunday, Sept. 28, 2014, in Arlington, Texas. (AP Photo/Brandon Wade)

ARLINGTON, Texas - DeMarco Murray ran over, around and through the Saints on Sunday night, and the Dallas Cowboys followed him to victory.

The Saints defense surrendered 149 yards and two touchdowns to Murray, the NFL's leading rusher, and Tony Romo added three TD passes as Dallas dominated en route to a 38-17 Saints loss at AT&T Stadium.

The Saints are now 1-3 entering next Sunday's NFC South matchup against Tampa Bay (1-3), their worst start to a season under Sean Payton.

Against the Cowboys (3-1), the Saints offense under Drew Brees was held scoreless in the first half, while Murray and the Cowboys took a 24-0 lead at halftime.

The Saints did not score their first TD until Brees found tight end Josh Hill on a 12-yard scoring reception early in the fourth quarter.

Murray scored on runs of 15 and 28 yards, while Romo threw for 262 yards.

Brees finished with 341 passing yards, two TDs and one interception.