Advocate photo by Jim Mustian -- New Orleans Mayor Mitch Landrieu speaks with Neera Tanden, President and CEO of the Center for American Progress.

The nation's biggest cities, even those in red states, tend to swing blue. So it should come as no surprise that the list of issues where President Donald Trump and the country's highest-profile mayors agree is a short one. It pretty much begins and ends with infrastructure, and even there, it's not at all clear that Trump's plans are in tune with various mayors' wants and needs.

And the list of issues where they diverge is both long and wide, covering everything from policing to voting rights to health care access to immigration to climate change to federal investment in housing.

So although the U.S. Conference of Mayors is a steadfastly bipartisan group, New Orleans Mayor Mitch Landrieu assumes the organization's presidency at a time when it's positioned to be more confrontational than cooperative. Yes, he stressed pragmatism over politics in his inaugural address Monday and contrasted the "radical center" he said mayors represent with the paralyzing partisanship of Washington, but reality will inevitably position the group on one side.

One interesting footnote is that he's not alone in bringing a New Orleans perspective to that role.

Already challenging the administration on many of the same fronts from the advocacy community is his predecessor as both mayor and Conference of Mayors president, Marc Morial, who now heads the National Urban League. Working some of the same angles from Capitol Hill is Cedric Richmond, the New Orleans congressman who leads the Congressional Black Caucus.

That's quite a 1-2-3 punch for any city. And it's particularly impressive coming from a relatively small town, as big cities go — not to mention one that's located deep in Trump Country.

Follow Stephanie Grace on Twitter, @stephgracela.