OXFORD, Miss. — For the second time in 364 days, the Ole Miss rushing defense was trampled by an LSU running back Saturday night.

First, it was Leonard Fournette, who gashed the Rebels for a then school-record 284 yards in the Tigers’ 38-21 romp in Tiger Stadium last Oct. 22.

This time, it was Derrius Guice, who rolled Ole Miss for 276 yards and a 7-yard touchdown in No. 24 LSU’s 40-24 blowout of the Rebels in Vaught-Hemingway Stadium.

At this point, Ole Miss’ battered defenders have to be wondering aloud: Who will be next if Guice decides to follow Fournette and declares for the NFL draft after this season?

Whoever it is will have a difficult time repeating what Fournette and Guice did to Ole Miss in back-to-back games.

And don’t forget Darrell Williams as well.

Fournette and Guice, who was hurt in the preseason and appeared to re-injure his left knee in a loss to Mississippi State, combined for 560 yards and a 14.7 average on 38 carries with four touchdowns in those two games.

For good measure, Williams added 103 yards rushing on 22 carries as LSU’s offensive line opened some gaping holes for their running backs.

Williams added 105 yards receiving on four catches with a 63-yard catch-and-run on the Tigers’ third offensive play of the game to set up a Connor Culp field goal.

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In doing so, Williams became the first player in LSU history to have 100 yards rushing and 100 yards receiving in the same game.

“That’s a team player,” Guice said of Williams. “When I got here, Darrel was the guy who knew everything about the offense.”

Guice, who was sidelined for the Troy loss on Sept. 30, had a total of 121 rushing yards in LSU’s wins over Florida and Auburn.

But he looked like the Derrius Guice of old Saturday night.

The junior surpassed his 121-yard rushing total of the past two weeks in the second quarter and had 126 yards on 11 carries by halftime and 268 yards on 18 attempts by the end of the third period.

At that point, Guice was just 18 yards shy of breaking the school-record 285-yard performance he had in a Thanksgiving night beating of Texas A&M.

After LSU put the game away on a 60-yard pass from Danny Etling to Foster Moreau with 10:24 left for a 37-16 cushion, Guice added 8 yards on four carries, but still wound up averaging 12.5 yards a try.

He came up 10 yards shy of breaking his own school mark.

“It wasn’t the old Derrius,” Guice said. “The way I’ve played this year, whether I was injured on not, there are no excuses. We came together as a team tonight and won.”

But on this cool night, it wasn’t just Guice, who reeled off long runs of 59, 48 and 33 yards against the beleaguered Rebels by the end of the third quarter.

“Big plays fuel emotions, that’s what coach (Ed Orgeron) always says,” Guice said. “Big plays get us going.”

As a team, the Tigers finished the game with 393 yards on 55 carries and piled up 593 total yards on 68 snaps.

Ole Miss went into the game 12th in the Southeastern Conference and 117th nationally in allowing 238.5 rushing yards per contest.

But Guice, who put together his third 250-yard game of his career — the first player in SEC history to do that — gained more yards than Ole Miss was giving up in the first three quarters alone.

“Derrius is a great guy, so when he’s healthy he makes plays,” left guard Garrett Brumfield said. “We just have to do our jobs as an offensive line."

“You saw it tonight,” center Will Clapp said of Guice. “He was about 10 yards from breaking his record. When he’s healthy, he’s unstoppable.”

Follow Sheldon Mickles on Twitter, @MicklesAdvocate.