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LSU safety Ed Paris (21) pushes Mississippi State running back Aeris Williams (22) out of bounds after a catch during the first half at Davis Wade Stadium Saturday Sept. 16, 2017, in Starkville, Miss..

LSU has at least temporarily lost another defender. 

Senior safety Ed Paris suffered an injury during Tuesday's practice and is expected to at least miss the game Saturday against Syracuse, coach Ed Orgeron said Thursday.

The injury is a significant one and is to his knee, a source confirmed. It could cost him more games and potentially the season.

"It doesn't look good for Ed," Orgeron said. "I haven't got the doctors report. Freak accident on field goal block. I'll have the doctor's report for tomorrow, but it definitely doesn't look good for him."

Paris appears to be eligible for a medical redshirt, despite playing for a portion of this season. The NCAA grants redshirts for medical reasons under two conditions: a players must not have played in the second half of the season and must not have played in more than one-third of a team's snaps. The Tigers have played three games, and Paris has not played each defensive snap.

Paris, a Texas native who's played in a reserve role until this season, has spent the last three games rotating with true freshman Grant Delpit at the safety position opposite John Battle. Paris played more last week in the 37-7 loss to Mississippi State than he had in the previous two games.

Paris shifted from cornerback to safety last season and entered preseason camp occupying a starting position, but Delpit leaped the veteran, starting the first three games. Redshirt freshman Eric Monroe and Xavier Lewis will see more time in the rotation with Paris out, Orgeron said. 

His absence comes on a week in which 25th-ranked LSU (2-1) hosts one of the most up-tempo, pass-heavy teams in the nation. The Orange (2-1) attempts 43.7 passes a game, ninth nationally, and throws for 297.3 yards a game. Among teams that have played three games, Syracuse has run more plays (265) than all but three Football Bowl Subdivision squads. 

Paris joins what's becoming a lengthy list of defensive players whose statuses are in question or who are unavailable ahead of Saturday's game.

Nose tackle Ed Alexander (hand injury) is out for this week's game, but he should return in "two weeks," the coach said Wednesday. Defensive end Rashard Lawrence (ankle injury) has missed the last two games but is expected to return for "some snaps," Orgeron said. Edge rusher Andre Anthony (ankle injury) has not practiced since suffering his injury during Week 1 of practice.

Defensive end Frank Herron, edge rusher Sci Martin and cornerback Kristian Fulton (presumed suspensions) have not dressed out for a game this season. Orgeron said Wednesday night that Herron will return for the Oct. 14 game against Auburn. 

Follow Ross Dellenger on Twitter, @RossDellenger.