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LSU running back Derrius Guice (5) runs free as Brigham Young linebacker Butch Pau'u (38) and Brigham Young defensive lineman Rhett Sandlin (46) give chase during the first half at LSU's football season opener against Brigham Young University Saturday Sept. 2, 2017, in New Orleans, La..

Running back Derrius Guice's status for LSU's game Saturday against Syracuse is in doubt. 

Guice, the Tigers' standout junior tailback, is "very questionable" for the game against the Orange (2-1), coach Ed Orgeron said Wednesday on the Southeastern Conference teleconference. Guice appeared to injure his left knee late in the third quarter of the 37-7 loss at Mississippi State.

"I don't know if Derrius is going to play," Orgeron said. "He didn't dress out yesterday in pads. He's very questionable right now."

Guice has missed the last two days of practice for what was believed to be precautionary reasons, according to comments from Orgeron and Guice on Monday. Guice described the injury as getting a "little nicked." Orgeron said the running back would be "fine" and that withholding him from practice was an effort at "protecting him."

The injury seems more serious. 

Guice appeared to hurt the knee during a run with less than 2 minutes left in the third quarter against the Bulldogs. He remained in for one more play, hobbling during a play-action attempt to him, before he limped off the field. 

He spoke to reporters Monday without a noticeable limp, even running out of the interview room. Guice is having a peculiar start to what is believed to be his final season in Baton Rouge. He's run for 300 yards and is averaging more than 5 yards a carry, but he hasn't played in the fourth quarter yet this year. He's missed what amounts to nearly a completed game (about 58 1/2 minutes).

Orgeron 'thinks' Lawrence will play

Defensive end Rashard Lawrence continues working his way back to full health and could play "some" snaps during Saturday's game against the Orange, Orgeron said on Wednesday. 

Lawrence, who Orgeron has called the most consistent defensive lineman, missed the last two games with an ankle injury he suffered in the season opener. 

"Rashard Lawrence has practiced in pads. Looks like he might be able to get us some snaps," Orgeron said. "Don't know how many snaps, but I think he's going to play."

Follow Ross Dellenger on Twitter, @RossDellenger.