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LSU interim head coach Ed Orgeron, center, sings the alma mater with his players after the LSU Missouri football game Saturday Oct. 1, 2016, in Tiger Stadium. LSU won 42-7.

LSU running back Leonard Fournette is expected to miss a second straight game when the Tigers play at Florida on Saturday, and two others starters could be out for the game against the Gators, coach Ed Orgeron said Wednesday on the SEC teleconference. 

Offensive lineman Will Clapp will miss the game, and tight end Foster Moreau is likely out, too, Orgeron confirmed. Clapp re-injured a right shoulder issue in the second quarter against Missouri, and Moreau hurt himself during the second half. Clapp will be out "two weeks," the coach said. LSU hosts Southern Miss next week.

"Doesn't look like Leonard is going to play. We don't know yet. He hasn't practiced yet," Orgeron said. "I do believe Will is going to be out the next couple of weeks. Foster Moreau will be out this week, but I'm not sure of that yet."

Fournette, once a Heisman Trophy favorite, continues to nurse a lingering left ankle injury. He sprained the ankle during preseason camp and then re-injured it in the season opener against Wisconsin and then again with the game at Auburn on Sept. 17.

The junior tailback missed Game 2 against Jacksonville State and last week's win over Missouri. Orgeron, at first this week, said he expected Fournette to return, but he backed off those comments on Monday after speaking with team trainers. 

Fournette has missed nearly two straight weeks of practice. Moreau and Clapp were also missing from practice Monday and Tuesday. 

Clapp's absence has resulted in some tinkering along LSU's starting offensive line. O-line coach Jeff Grimes moved center Ethan Pocic to right tackle during drills Tuesday. Andy Dodd played center, and Maea Teuhema moved from right tackle to left guard.

"Jeff Grimes is managing his position," Orgeron said when asked Wednesday. "There's some things with Will Clapp being out that we're experimenting with. We'll see how the week goes."

Orgeron not focused on hurricane

As Hurricane Matthew bares down on the Florida coast, Orgeron is focused on his team, he said Wednesday.

"We'll let the administration handle that," he said. "It's 'Turnover Wednesday.' We're focused on going up there. No plans have changed yet. If anything has changed, the administration will let me know."

Florida's president was expected to meet with emergency officials this morning. The status of the game is in doubt as Matthew barrels toward the Florida coast. 

Follow Ross Dellenger on Twitter, @RossDellenger.