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LSU running back Derrius Guice (5) signals first down after the run during the first half Saturday, Nov. 28, 2015, in Tiger Stadium. Guice opens the season in the conversation for the Heisman Trophy.

Ed Orgeron expects running back Derrius Guice to play in LSU’s season opener against BYU on Saturday, but, three days before kickoff, that decision has yet to be made.

“We have not made a final decision yet. Looks like he’s going to play. I don’t believe he’s 100 percent right now,” Orgeron said Wednesday on the SEC teleconference. “We will see towards the end of the week, but I do expect him to play.”

During interviews Tuesday, Guice said a tooth issues had kept him out of practice all last week. Fellow running back Clyde Edwards-Helaire posted a message on Twitter last week with photos of Guice having swollen lips and a swollen jaw from surgery to remove his wisdom teeth, Edwards-Helaire wrote.

Orgeron declined to confirm the tooth issue when asked about it Monday. Guice claimed he was 100 percent and “ready to go.”

“My teeth aren’t holding me back,” Guice said Tuesday. “I don’t care if they pull all of them out. I’ll be ready this week.”

The loss of Guice could potentially mean that the Tigers will play their opener without their two most decorated players. Guice and edge rusher Arden Key have landed on multiple preseason award watch lists and All-American teams.

Key is out while recovering from May shoulder surgery.

Follow Ross Dellenger on Twitter, @RossDellenger.