Alabama coach Nick Saban says freshman running back Trey Sanders is "out indefinitely" with a foot injury.
Saban said Saturday the injury will require surgery. He did not provide further details.
According to an AL.com report, Sanders will likely miss the 2019 season while he recovers.
Saban says defensive tackle DJ Dale will likely miss about a week with a sprained knee. Linebacker Joshua McMillon also sustained "a potential knee injury." AL.com reports that McMillon will likely miss the entire season.
Joe Burrow returned to practice Monday afternoon.
Sanders was rated the nation's No. 6 overall prospect and top running back in the 247Sports composite rankings.
He was likely to contend for playing time behind Najee Harris, with Brian Robinson also returning to the backfield.
Depth could become an issue for the Crimson Tide, which had to replace leading rusher Damien Harris and first-round NFL draft pick Josh Jacobs.
Alabama also has freshman running back Keilan Robinson and redshirt freshman Jerome Ford.
Breiden Fehoko returned a fumble in LSU's scrimmage — until quarterback Myles Brennan tackled him.