LSU had a pair of effective quarterbacks Saturday.

Ailing Florida, try as it might, couldn't find one, or at least a healthy one, that could move the Gators offense against LSU's rugged defense.

Jarrett Lee and Jordan Jefferson both had their moments under center as No. 1 LSU overwhelmed No. 17 Florida, playing without its top two quarteracks, 41-11 at Tiger Stadium. It was LSU's most lopsided win over Florida since 1971.

"It was all about the Tigers today," head coach Les Miles said.

Jarrett Lee passed for 154 yards, including two long bombs to Rueben Randle, while Jefferson came off the bench to engineer scoring drives on his first two drives as LSU (6-0, 3-0 in the SEC) jumped on Florida, which played without its top two quarterbacks, early.

Florida (4-2, 2-2) played without starting quarterback John Brantley and backup Jeff Driskel, both sidelined with ankle injuries suffered in last week's 38-10 loss to Alabama.

Lee completed 7-for-10 passes for the Tigers, hitting Randle for a 46-yard touchdown on LSU's second play while adding a 57-yard pass to Randle late in the game to set up another score.

Randle caught four passes for 127 yards.

"He had a huge afternoon," Miles said of Randle.

Jefferson, playing in his second game after being suspended the first four, came off the bench to engineer a touchdown drive and a field goal drive and also entered two Lee-led drives near the goalline and finished them with touchdowns, the first on a 3-yard touchdown pass, a Tim Tebow-style jump pass, for another score.

Jefferson completed 3-of-4 passes for 61 yards and the 3-yard score to Mitch Joseph, the senior tight end's first career score.

Miles said while both "can be better," he "thought we did some good things with both. They both played well. I think we can do even better. There were some things we didn't do with both guys. We felt that when victory was secure there were things that were out of the playbook."

While LSU had its way under center, UF struggled with true freshman Jacoby Brissette seeing not only his first snaps of his career, but making his first start.

Brissette completed 8-of-14 passes for 94 yards and a touchdown, but he was intercepted twice.

"I thought he was solid, especially under the circumstances," said Florida coach Will Muschamp, the former LSU assistant coach. Muschamp said Brissette was given the nod Wednesday after it became apparent that Driskel was not healthy enough to play "in this environment."

Driskel, the more highly-rated of the two true freshmen, finished the Alabama game after Brantley went down with what was reported to be a high ankle sprain.

Florida also used running backs Trey Burton, a former quarterback, and Chris Rainey in Wildcat situations. At time, all three would take snaps on the same drive.

While Lee and Jefferson both had moments, LSU mostly battered Florida with its running game. Spencer Ware had 109 yards on 24 carries and two touchdowns while Alfred Blue added 70 yards on 14 carries and another score.

As a team, LSU had 238 yards on 49 carries. LSU ran on 49 of its 63 plays.

"We rushed the football at the back end of the game when we had to so that we could take our opponent out of the game," Miles said.

With the running game controlling the clock -- and with Florida struggle to sustain any success against LSU's defense -- LSU held the ball for 35:40, including 24:41 of the second half. LSU had 20 first downs to nine for Florida.

"We've got to come up with some ways to stop the run game better than we're doing at this point," Muschamp said.

LSU scored on its first two possessions, on the Lee-to-Randle touchdown pass and on a the first drive and a 2-yard run by Ware on the second drive. LSU never looked back.

Tyrann Mathieu and Brandon Taylor both intercepted Brissett passes for LSU's defense, which has forced 14 turnovers this year while the Tigers offense, turnover free Saturday, has committed just three turnovers.

"Our defense goes on the field and makes it very difficult for our opponent to drive the field," Mies said.

The game featured on of the year's oddest plays. LSU punter Brad Wing apparently scored on a 52-yard run on a fake in the second quarter, but he was penalized for taunting Florida, holding the ball out at the 8-yard line on his way to the end zone.

Miles said he thought it was the right call, saying "we'll learn from it."

LSU piled up 453 offensive yards to just 213 for Florida, 65 of which came on one play. UF's only touchdown was a 65-yard Brissett-to-Andre Debose touchdown pass in the third quarter.

LSU held Florida's star running back tandem, Chris Rainey and Jeff Demps, to 52 yards on 15 carries. All the yards came from Rainey's 13 attempts.