Drew Brees passed for 337 yards and two second-half touchdowns to Marques Colston and the New Orleans Saints held off the Tennessee Titans, 22-17 Sunday at Nashville, Tenn.

Jo-Lonn Dunbar sacked Tennesee quarterback Jake Locker on the game's last play after Tennessee drove to the Saints' 5-yard line. The Titans ran two plays from the 5, an incompletion, then Dunbar's sack of Locker as time expired.

Brees hit Colston for touchdowns of 35 and 28 yards in the second half as the Saints (10-3) overcame a first half where they were limited to three field goals. Despite the slow start, New Orleans was able to win its fifth straight.

The Saints had to hold off a late rally led by Locker, the rookie who came in for an injured Matt Hasselbeck. After the second Brees-to-Colston TD gave New Orleans a 22-10 lead with 7:08 left, Locker hit Nate Washington for a 40-yard touchdown to pull Tennessee (7-6) wihtin 22-17 with 6:05 left.

Tennessee (7-6) forced a punt and drove to the Saints 23, but Locker's attempt at a 4th-and-inches sneak was stuffed short with just over two minutes left. The Saints again had to punt, and Locker drove the Titans to the 5 after a 40-yard pass to Washington.

But the Saints' Tracy Porter broke up a pass into the end zone with five seconds left. Then on the game's last play, Locker rolled out, could not find a receiver, then was brought down by Dunbar.

Locker, a rookie from Washington, went 13-for-29 for 282 yards and also rushed for a team-best 36 yards on six carries after Hasselbeck left with a calf injury.

The Saints held Tennessee star running back Chris Johnson to 23 yards on 11 carries while Chris Ivory, activated for the injured Mark Ingram, rushed for 53 yards on 13 carries for the Saints.

Brees completed 36 of 47 passes for the Saints and Colston caught seven passes for 105 yards.